Md Salahuddin, Sunil Kakad, S. M. Shantakumar, "Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity", Journal of Chemistry, vol. 6, Article ID 361282, 8 pages, 2009. https://doi.org/10.1155/2009/361282
Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity
Bromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone (4) yielded (5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine [6(a-g)]. However reaction of (5) with 4-chloro-2-triflouro acetyl aniline provided (6h). Similarly reaction of (5) with 5-amino tetrazole & 2-amino benzimidazole produced (6i) & (6j) respectively. All the synthesized compounds were tested against bacteria (Gram positive and Gram negative).
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