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Md Salahuddin, Sunil Kakad, S. M. Shantakumar, "Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity", Journal of Chemistry, vol. 6, Article ID 361282, 8 pages, 2009. https://doi.org/10.1155/2009/361282
Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity
Abstract
Bromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone (4) yielded (5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine [6(a-g)]. However reaction of (5) with 4-chloro-2-triflouro acetyl aniline provided (6h). Similarly reaction of (5) with 5-amino tetrazole & 2-amino benzimidazole produced (6i) & (6j) respectively. All the synthesized compounds were tested against bacteria (Gram positive and Gram negative).
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Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
