Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 361282 | 8 pages | https://doi.org/10.1155/2009/361282

Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity

Received14 Dec 2008
Accepted05 Feb 2009

Abstract

Bromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone (4) yielded (5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine [6(a-g)]. However reaction of (5) with 4-chloro-2-triflouro acetyl aniline provided (6h). Similarly reaction of (5) with 5-amino tetrazole & 2-amino benzimidazole produced (6i) & (6j) respectively. All the synthesized compounds were tested against bacteria (Gram positive and Gram negative).

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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