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E-Journal of Chemistry
Volume 6 (2009), Issue 3, Pages 796-800

Syntheses, Characterization and Biological Activity of Some 1, 2, 4-Triazole Derivatives

R. J. Singh1 and D. K. Singh2

1Quality Control Laboratory, IOCL, Panipat Refinery, Panipat, Haryana-132140, India
2Synthetic Research Laboratory, Department of Chemistry, Faculty of Science, T.D.P.G. College, Jaunpur-222002, India

Received 1 December 2008; Accepted 4 February 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Syntheses of a series of 3-alkyl-4- amino-5- cyanomethyl-4H-1, 2, 4-triazoles with active methylene groups are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. All the compounds carrying 1, 2, 4- triazole moiety showed significant biological activity.