Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 451967 | https://doi.org/10.1155/2009/451967

R. Singh Gujral, S. Manirul Haque, P. Shanker, "A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin", Journal of Chemistry, vol. 6, Article ID 451967, 8 pages, 2009. https://doi.org/10.1155/2009/451967

A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin

Received01 Apr 2009
Accepted05 Jun 2009

Abstract

An accurate and validated spectrophotometric method was developed for the determination of gabapentin. This is simple, sensitive and low cost UV spectrophotometric method. The method is based on the direct measurement of the native absorbance of the drug. The detection was done at 210 nm. The method was linear in the range of 0.25 - 3.5 µ g/mL with correlation coefficient of 0.9999. It is validated according to the ICH guidelines with respect to linearity, selectivity, accuracy and precision, limit of quantitation and limit of detection. The method has been applied to assess gabapentin in pharmaceutical formulations with good accuracy and precision and relatively free of interference from coexisting substances.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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