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UV Spectrophotometric Determination of Aripiprazole in Bulk and Pharmaceutical Formulation
R. Kalaichelvi
,1 B. Thangabalan,2 D. Srinivasa Rao,1 and E. Jayachandran31K.C.Reddy Institute of Pharmaceutical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur-522 348, India
2Department of Pharmacy, Donbosco PG College, 5th mile, Vatticherukuru Mandal, Pulladigunta, Guntur-522 017, India
3S.C.S. College of Pharmacy, Harapanahalli-583131., Devanagari Dist, Karnataka, India
Abstract
A simple, sensitive and reproducible spectrophotometric method was developed for the determination of aripiprazole in pure form and in pharmaceutical formulation. It has an absorption maximum at 219 nm and obeys beer's law in the concentration range 2- 10 µg mL-1. Results of analysis were validated statistically and by recovery studies. The apparent molar absorptivity and sandell's sensitivity were 5.2 x 105 L mol-1 cm-1 and 8.4 x 10-3 µg cm-2, respectively. The slope and intercept of the equation of the regression line are 0.0035 and 0.1155 respectively. Correlation coefficient was found to be 0.9998. This method is successfully employed for the determination of aripiprazole in pharmaceutical preparation.
Copyright
Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
