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E-Journal of Chemistry
Volume 6, Issue 4, Pages 943-948
http://dx.doi.org/10.1155/2009/670617

Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f.

M. Kamalutheen,2 S. Gopalakrishnan,1 and T. Syed Ismail2

1Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627012, Tamilnadu, India
2Department of Chemistry, Sadakathullah Appa College, Palayamkottai, Tirunelveli, Tamilnadu, India

Received 18 February 2009; Accepted 4 April 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The various extracts of Merremia tridentate were investigated for its anti-inflammatory and anti-arthritic activities in male albino rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw oedema model and the anti-arthritic activity was carried out using complete Freund’s adjuvant induced arthritis model. Indomethacin (10 mg/kg bw) was used as a standard drug. The ethanol extract of M. tridentate exhibited significant dose dependent activity in acute inflammation and the doses of 100 mg/kg bw and 200 mg/kg bw produced 38.3% and 42.8% inhibition respectively after 3 h as compared with that of the standard drug which showed 48.5% inhibition. In arthritis model, the doses of 100 mg/kg bw and 200 mg/kg bw of the ethanol extract produced 49.0% and 51.7% inhibition respectively after 19 days when compared with that of the standard drug (55.5%). Both doses of the ethanol extract of M. tridentate exhibit significant anti-inflammatory and anti-arthritic activities.