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E-Journal of Chemistry
Volume 6 (2009), Issue 4, Pages 1133-1138

Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents

Niti Bhardwaj,1 S. K. Saraf,1 Pankaj Sharma,2 and Pradeep Kumar3

1Northern India Engineering College, Lucknow, India
2Raj Kumar Goel Institute of Technology, Ghaziabad, India
3PES College of Pharmacy, Bangalore, India

Received 9 March 2009; Accepted 15 April 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activities etc. It is well known that the synthesis of heterocyclic compounds tend to contain multi-structure in a molecule. The ring formation involves the condensation reaction. The challenge is to develop the ring system by incorporating the indole nucleus into it through the proposed reaction scheme. There are two free positions for the substitution in the oxadiazole ring system. In this study, it was planned to incorporate the oxadiazole ring system into indole ring. Synthesis of derivatives of 1,3,4-oxadiazoles from different benzaldehydes Characterization of the synthesized compounds along with their antimicrobial activity on different strains.