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E-Journal of Chemistry
Volume 6, Issue 3, Pages 759-762
http://dx.doi.org/10.1155/2009/874389

Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents

Shriram Bairagi, Ashok Bhosale, and Meenakshi N. Deodhar

Department of Pharmaceutical Chemistry, SGRS College of Pharmacy, Saswad, Pune-412301, India

Received 7 November 2008; Accepted 12 December 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

4-Chloro-2-oxo-2H-chromene-3-carbaldehyde (2) was reacted with different anilines in rectified spirit as solvent to yield a series of the title compounds i.e. 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2-one (3a-i). These compounds were charaterised on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 3C was found to be most active with an MIC of 15 μg /mL against all the tested organisms.