Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 895948 | 7 pages |

Spectrophotometric Determination of Ceftiofur Hydrochloride Using N-Bromosuccinimide and p-Dimethylaminobenzaldehyde

Received22 Oct 2008
Accepted12 Dec 2008


Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of ceftiofur based on the formation of oxidation and condensation products. Method A involves the oxidation of the ceftiofur (CEFT) with N-bromosuccinimide (NBS) and determination of the unconsumed NBS with p-N-methylaminophenol (PMAP)-sulfanilamide (SA) (PMAP-SA) reagent. Method B includes the determination of unreacted NBS using a known excess of celestine blue (CB) and measuring the remaining dye. Condensation of p-dimethylaminobenzaldehyde (PDAB) with the drug was the basis of method C. Determination of CEFT in bulk form and in pharmaceutical formulations was also incorporated.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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