V. Annapurna, G. Jyothi, C. Rambabu, B. B. V. Sailaja, "Spectrophotometric Determination of Ceftiofur Hydrochloride Using N-Bromosuccinimide and p-Dimethylaminobenzaldehyde", Journal of Chemistry, vol. 6, Article ID 895948, 7 pages, 2009. https://doi.org/10.1155/2009/895948
Spectrophotometric Determination of Ceftiofur Hydrochloride Using N-Bromosuccinimide and p-Dimethylaminobenzaldehyde
Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of ceftiofur based on the formation of oxidation and condensation products. Method A involves the oxidation of the ceftiofur (CEFT) with N-bromosuccinimide (NBS) and determination of the unconsumed NBS with p-N-methylaminophenol (PMAP)-sulfanilamide (SA) (PMAP-SA) reagent. Method B includes the determination of unreacted NBS using a known excess of celestine blue (CB) and measuring the remaining dye. Condensation of p-dimethylaminobenzaldehyde (PDAB) with the drug was the basis of method C. Determination of CEFT in bulk form and in pharmaceutical formulations was also incorporated.
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