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E-Journal of Chemistry
Volume 6, S1, Pages S254-S258

Synthesis and Antimicrobial Activity of 1-[2-(10-p-Chlorobenzyl) phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones

R. K. Upadhyay, Megha S. Upadhyay, and S. Jain

Chemistry Department N.R.E.C. College, Khurja, India

Received 9 October 2008; Accepted 5 December 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aiming at the development of antimicrobial agents, we have synthesized nine chlorobenzyl substituted phenothiazinyl chalcones by condensing 2-acetyl phenothiazine with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen - Schmidt condensation and subsequent reaction of products with p-chlorobenzyl bromide. Structures of these compounds were elucidated by their IR, 'H NMR spectroscopic data and microonalyses. The antimicrobial activity of the new products was evaluated by Filter Paper Disc Method.