Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 925964 | 6 pages | https://doi.org/10.1155/2009/925964

Syntheses of Some 3,5-Diaryl-4H-1,2,4-triazole Derivatives and their Antifungal Activity

Received03 May 2009
Accepted01 Jul 2009

Abstract

Syntheses of a series of 3, 5-diaryl-4H-1, 2, 4-triazole derivatives are described. In this present work, 4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole(1) was converted to N,N’-bis[3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine(2) and 3-Phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4-triazole (3) in good yields by treatment with aldehydes OHC-C6H4-CHO and Ar-CHO respectively. The compounds N,N’-bis [3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine (2) and 3-phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4-triazole (3) were reduced with NaBH4 to afford the corresponding compounds N,N’-bis [3-phenyl-5--tolyl-4H-1,2,4-triazolyl]-1,4-xylenediamine (4) and 3-phenyl-5-p-tolyl-4-[4-methyl benzylamino]-4H-1,2,4-triazole (5) respectively. The newly synthesized compounds were characterized by spectral and elemental analyses. All the synthesized compounds were tested for their antifungal activity against P.oryzae, B. cinerea, A. niger, C. albicans and T. rubrum.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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