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E-Journal of Chemistry
Volume 6, Issue 4, Pages 1047-1054
http://dx.doi.org/10.1155/2009/937528

Mining the Information for Structure Based Drug Designing by Relational Database Management Notion

R. Balajee1 and M. S. Dhanarajan2

1Department of Bioinformatics, Sathyabama University, Chennai, India
2Jaya College of Arts and Science, Thiruninravur-602 024, India

Received 6 January 2009; Accepted 5 March 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Structure based drug design is a technique that is used in the initial stages of a drug discovery program. The role of various computational methods in the characterization of the chemical properties and behavior of molecular systems is discussed. The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role for validating drug targets. By integrating data from many inter-related yet heterogeneous resources, informatics can help in our understanding of complex biological processes and help improve drug discovery. The determination of the three dimensional properties of small molecules and macromolecular receptor structures is a core activity in the efforts towards a better understanding of structure-activity relationships.