Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 102162 | 8 pages | https://doi.org/10.1155/2010/102162

A New Ritodrine Selective Electrode and its Pharmaceutical Application

Received13 Feb 2010
Accepted08 Apr 2010

Abstract

A novel ritodrine hydrochloride ion-selective PVC membrane electrode based on ion-pair complex of ritodrine-tetra phenyl borate was prepared with di-n-butyl phosphate as a plasticizer. The influences of membrane composition, temperature, pH of the test solution and foreign ions on the electrode performance were investigated. The electrode showed a Nernstian response over a wide ritodrine concentration range (1×10−5- 1×10−2 M) with a slope of 59.33 mV decade−1 and was found to be very selective, precise and usable within the pH range 3-7.5. The standard electrode potentials, E°, were determined at different temperatures and used to calculate the isothermal temperature coefficient (dE°/dT) of the electrode, which was 0.00075. The electrode was successfully used for potentiometric determination of ritodrine hydrochloride both in pure solutions and in pharmaceutical preparations.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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