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E-Journal of Chemistry
Volume 7, Issue 4, Pages 1396-1406

Synthesis, Characterization and Antibacterial Activity of Schiff Bases and their Metal Complexes Derived from 4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones and 2-Amino-4(4'-methylphenyl)-thiazole

A. S. Thakar,1 K. K. Singh,1 K. T. Joshi,2 A. M. Pancholi,2 and K. S. Pandya3

1Zydus Research Centre, Ahmedabad-382 210, India
2Department of Chemistry, Navjivan Science College, Dahod-389 151, India
3Sir P.T. Science College, Modasa-383 315, India

Received 5 February 2010; Accepted 2 April 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones condensed with 2-amino-4(4'-methylphenyl)-thiazole to form Schiff base. These Schiff bases from complexes of type ML22H2O (M=Mn, Fe, Co, Ni and Cu). Elemental analysis, magnetic susceptibility, electrical conductance, electronic and Infrared spectral data suggested octahedral structure for the complexes. All the compounds were tested for their antibacterial activity. The result indicates that the growth of the tested organism was inhibited by most of the compounds. These Schiff bases are characterized by elemental analysis, mass spectra, 1H-NMR spectra, 13C NMR spectra and FT IR spectra.