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E-Journal of Chemistry
Volume 7, Issue 1, Pages 37-40
http://dx.doi.org/10.1155/2010/168651

Novel Syntheses of Some 1, 2, 4-Triazoles as Potent Bacteriocidal Agents

Ram Janam Singh1 and Dharmendra Kumar Singh2

1Quality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery Panipat, Haryana-132140, India
2Department of Chemistry, Synthetic Research Laboratory, Faculty of Science, Tilak Dhari Post Graduate College, Veer Bahadur Singh Purvanchal University, Jaunpur-222002 (U.P), India

Received 20 March 2009; Revised 15 June 2009; Accepted 10 August 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A facile syntheses of 4-aryl-5-(isomeric pyridoyl)-3H-1, 2, 4-triazoles as potent bacteriocidal agents are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P.aeruginosa. All compounds carrying 1, 2, 4- triazole moiety showed significant biological activity