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E-Journal of Chemistry
Volume 7 (2010), Issue 2, Pages 545-550

Synthesis and Biological Activity of Some Novel 4-(5-Mercapto-1,3,4-thiadiazol-2-yl)-2-phenyl-5-[2-phenylvinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Kumar Sanjeev S. Lamani and Oblennavar Kortesh

Department of Chemistry, Karnataka Unversity’s Karnatak Science College, Dharwad-580001, Karnataka, India

Received 28 July 2009; Accepted 20 September 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel and efficient route have been designed for the synthesis of 4-(5-mercapto-1,3,4-thiadiazol-2-yl)-2-phenyl-5-[2-phenylvinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one. All the synthesized compound were characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectra. All the synthesized products were evaluated for their antibacterial activity against B. Subtilis and E.Coli and antifungal activity against A. niger and C.Albican respectively. The results indicate that the present compounds may serve as better fungicides when compared to bactericides. The synthesized compounds have turned to be wonder by possessing antimicrobial properties.