Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 237473 | 6 pages | https://doi.org/10.1155/2010/237473

Synthesis, Antibacterial and Analgesic Activities of 4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl) sydnones

Received08 Apr 2009
Revised23 May 2009
Accepted20 Jul 2009

Abstract

A series of sydnone derivatives containing styryl ketone moiety, 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl)sydnones (6a-i) has been synthesized and characterized by spectral data. The synthesized compounds have been screened for preliminary antibacterial activity by cup plate method and analgesic activity by the method of acetic acid induced writhing in mice. The chloro and nitro derivatives showed good antibacterial activity against both gram positive and gram negative bacteria while the chloro and furyl derivatives exhibited highest analgesic effect among the series.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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