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E-Journal of Chemistry
Volume 7 (2010), Issue 1, Pages 59-64

Synthesis, Antibacterial and Analgesic Activities of 4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl) sydnones

Shreenivas R. Deshpande1 and K. Vasantakumar Pai2

1Department of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, BVVS Campus, Bagalkote-587 101, Karnataka, India
2Department of Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Shimoga Dist., Karnataka, India

Received 8 April 2009; Revised 23 May 2009; Accepted 20 July 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of sydnone derivatives containing styryl ketone moiety, 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl)sydnones (6a-i) has been synthesized and characterized by spectral data. The synthesized compounds have been screened for preliminary antibacterial activity by cup plate method and analgesic activity by the method of acetic acid induced writhing in mice. The chloro and nitro derivatives showed good antibacterial activity against both gram positive and gram negative bacteria while the chloro and furyl derivatives exhibited highest analgesic effect among the series.