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E-Journal of Chemistry
Volume 7, Issue 4, Pages 1523-1529
http://dx.doi.org/10.1155/2010/350754

Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents

V. Annapurna,1 G. Jyothi,1 A. V. Subbayamma,1 and B. B. V. Sailaja2

1Department of Chemistry, St. Theresa’s College for Women, Eluru-534003, India
2Andhra University, Visakhapatnam, Andhra Pradesh, India

Received 28 August 2009; Revised 31 December 2009; Accepted 20 February 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of buclizine (BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic acid/ p-N-methyl aminophenol sulphate (PMAP)-Cr(VI), the complex formation with cobalt thiocyanate (CTC) in method B and inner complex formation of BUCZ with sodium nitroprusside hydroxylamine hydrochloride and sodium carbonate in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system Determination of BUCZ in bulk form and in pharmaceutical formulations were also incorporated.