Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 415723 | 4 pages |

Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines

Received12 Jul 2009
Accepted27 Aug 2009


A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR, 1H NMR, and Mass spectral data. All the final compounds were evaluated for their in vitro antimicrobial activity.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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