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E-Journal of Chemistry
Volume 7, Issue 1, Pages 295-298

Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines

B. C. Revanasiddappa,1 R. Nagendra Rao,2 E. V. S. Subrahmanyam,1 and D. Satyanarayana1

1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatee-574160, Mangalore, Karnataka, India
2Department of Pharmaceutical Chemistry, S.C.S. College of Pharmacy, Harapanahalli, Karnataka-583 131, India

Received 12 July 2009; Accepted 27 August 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR, 1H NMR, and Mass spectral data. All the final compounds were evaluated for their in vitro antimicrobial activity.