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E-Journal of Chemistry
Volume 7 (2010), Issue 3, Pages 856-860
http://dx.doi.org/10.1155/2010/434379

Development of Rapid UV Spectrophotometric Method for the Estimation of Efavirenz in Formulations

Y. Anand Kumar1 and N. Rama Rao2

1Department of Pharmaceutics, V.L.College of Pharmacy, Raichur-584103, India
2Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, India

Received 31 July 2009; Accepted 20 October 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Simple, sensitive, accurate, precise and rapid ultraviolet (UV) spectrophotometric method was developed for the estimation of efavirenz in pure form, its formulations and stability samples. For the estimation of efavirenz, solvent system employed was 1% w/v sodium lauryl sulphate (SLS) and wavelength of detection (λdet) was 247 nm. The developed method was used to estimate the total drug content in two commercially available oral formulations of efavirenz and recovery studies were also carried out. Sample recovery in both the formulations using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and non-interference of formulation excipients in the estimation. The developed method was found to be stability specific and were validated as per ICH guidelines-2005, USP-2000 and statistical methods.