Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 467564 | https://doi.org/10.1155/2010/467564

Reda M. Abdel-Rahman, Mohammad Saleh I. T. Makki, Wafa A. Baker Bawazir, "Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II", Journal of Chemistry, vol. 7, Article ID 467564, 10 pages, 2010. https://doi.org/10.1155/2010/467564

Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II

Received17 Feb 2010
Accepted22 Apr 2010

Abstract

Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as six-membered rings such as; N,Nʼ-disubstituted-thiobarbituric acid, 3-thioxo-1,2,4-triazino[5,6-b]indole, 3-sulfanilamido-1,2,4-triazino[5,6-b]indole and 2-trifluoromethyl-4-imino-6-(sulfamido)1,3,5-triazino [3,2-a]indole derivatives (2-13) have been synthetically derived from the interaction of sulfa drugs with fluorine organic compounds (aldehydes, ketones, anhydride) followed by ring closure reactions. Structures of the targets have been established from their elemental and spectral data. Compounds 3, 6, 10 and 13 could be used as photochemical probe agents in compared with nystatin and nalidixic acid for inhibition of vitiligo diseases.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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