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E-Journal of Chemistry
Volume 7, Issue 4, Pages 1162-1169

An Efficient Solvent-Free Protocol for the Synthesis of 1-Amidoalkyl-2-naphthols using Silica-Supported Molybdatophosphoric Acid

Abdolkarim Zare,1 Alireza Hasaninejad,2 Esmael Rostami,1 Ahmad Reza Moosavi-Zare,3 Nasrin Pishahang,1 Mehrnoosh Roshankar,1 Fatemeh Khedri,1 and Maasoomeh Khedri1

1Department of Chemistry, Payame Noor University (PNU), Iran
2Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
3Faculty of Chemistry, Bu-Ali Sina University, Hamadan 6517838683, Iran

Received 10 November 2009; Accepted 5 January 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A highly efficient, green and simple solvent-free method for the synthesis of 1-amidoalkyl-2-naphthols via one-pot multi-components condensation of 2-naphthol, aromatic aldehydes and amides in the presence of catalytic amount of silica-supported molybdatophosphoric acid (H3PMo12O40.xH2O/SiO2, 3.17 mol%) is described. The reactions proceed rapidly and the title compounds are produced in high to excellent yields.