Table of Contents Author Guidelines Submit a Manuscript
E-Journal of Chemistry
Volume 7 (2010), Issue 1, Pages 234-238
http://dx.doi.org/10.1155/2010/524124

Synthesis of Some Phenylpyrazolo Benzimidazolo Quinoxaline Derivatives as Potent Antihistaminic Agents

C. H. Sridevi, K. Balaji, A. Naidu, and R. Sudhakaran

Dept. of Pharmaceutical Chemistry, Geethanjali College of Pharmacy, Cheeryal(V), Keesara(M), Hyderabad-501301, India

Received 22 May 2009; Accepted 15 July 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

2,3-Diphenyl quinoxaline (NI) was fused with benzimidazole (NII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (NIV) was made to react with different aromatic aldehydes to give chalcones (NV1-NV5). Chalcones refluxed with substituted acid hydrazides to afford different phenyl pyrazolo benzimidazole quinoxaline derivatives (NVI 1-NVI 15). The structure of chalcones and phenyl pyrazolo benzimidazole quinoxaline derivatives were confirmed by m.p, TLC and spectral data. All the synthesized compounds were screened for their antihistaminic activity. Compounds NVI-3, NVI-12, NVI-13, NVI-14 and NVI-15 were shown good % protection of antihistamic activity.