Table of Contents Author Guidelines Submit a Manuscript
E-Journal of Chemistry
Volume 7, Issue 4, Pages 1435-1439
http://dx.doi.org/10.1155/2010/543125

Synthesis and Biological Evaluation of 2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)-N'-(substituted phenyl-methyledene/ethylidene)acetohydrazides

Gopal Krishna Rao,1 R. B. Kotnal,1 and P. N. Sanjay Pai2

1Department of Pharmaceutical Chemistry, Department of Quality Assurance Al-Ameen College of Pharmacy, Opp. Lalbagh Main Gate, Hosur Road Bangalore-560 027, India
2Department of Quality Assurance , Al-Ameen College of Pharmacy, Opp. Lalbagh Main Gate, Hosur Road Bangalore-560 027, India

Received 15 January 2010; Accepted 10 March 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of quinoxaline derivatives was prepared and evaluated for antitubercular, antibacterial and antifungal activities. The title compounds were prepared by condensation of substituted aromatic aldehydes and substituted acetophenones with 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl) acetohydrazide. Structures of all these compounds were confirmed by their spectral studies. Among synthesized compounds (4r, 4t, 4u, 4w and 4x) have shown good anti tubercular activity (25 µg mL-1) when compared to reference drugs pyrazinamide (10 µg mL-1) and streptomycin (7.5 µg mL-1). In this study, few derivatives showed broad spectrum of antimicrobial activity at low concentration. The MICs (Minimum inhibitory concentration) of some compounds are 2-4 µg mL-1.