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Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity
Anjali Jha
,1 Y. L. N. Murthy,2 G. Durga,3 and T. T. Sundari41Department of Chemistry, Gitam Institute of Science, GITAM University, Rushikonda, India
2Department of Organic Chemistry and FDW, Andhra University, India
3Department of Chemistry, St. Josephs College for Women, Visakhapatnam, 530004, India
4NFMC, Bharatidasan University, Tiruchirapalli, 620024, India
Abstract
Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.
Copyright
Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
