Javed I. Sheikh, H. D. Juneja, V. N. Ingle, "A Computational Approach towards the Development of Newer Anticancer Agents", Journal of Chemistry, vol. 7, Article ID 582710, 4 pages, 2010. https://doi.org/10.1155/2010/582710
A Computational Approach towards the Development of Newer Anticancer Agents
In silico molecular docking analyses of the novel 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-aryl-propane-1, 3-diones were performed in the active sites of enzyme cytochrome P450 reductase to obtain new anticancer agents computationally. 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-(4"-methoxy-phenyl)-propane-1, 3-dione (3f) was found to have maximum affinity for the active sites of enzyme.
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