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E-Journal of Chemistry
Volume 7 (2010), S1, Pages S61-S66

Antibacterial Activity of Quaternary Ammonium Salt from Diethylaminoethyl Methacrylate

Makhloufia Mohammed,1 BenaÏssa Tahar,1 Derdour AÏcha,2 and Henni Djamel Eddine3

1Physical Chemistry Studies Laboratory University of Dr. Moulay Tahar, Sa├»da – 20000, Algeria
2Applied Organic Chemistry Laboratory, University of Esénia, Oran-31000, Algeria
3Phytopathology Laboratory, University of Esénia, Oran-31000, Algeria

Received 21 January 2010; Accepted 21 March 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A quaternary ammonium salt was synthesized from diethylaminoethyl methacrylate (DEAEMA) by quaternization with hexadecyl bromide. The resultant compound (Am-h) was characterized by FTIR and NMR spectroscopy. Its bactericidal activity was evaluated by determining minimum inhibitory concentration (MIC) values and inhibitory zone diameter against gram positive bacteria (Streptococcus sp.) and gram negative bacteria such as Acenito baumannii, Klebsiella pneumoniae and Proteus sp. respectively. The results showed that the MIC values of the synthesised compound (Am-h) were 2 μg/mL against Acenito baumannii, Klebsiella pneumoniae, Proteus sp. and Streptococcus sp.