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E-Journal of Chemistry
Volume 7, Issue 1, Pages 281-286

A Facile Microwave Assisted One-pot Strategy for the Synthesis of Bis-hexahydroquinazolin-5(6H)-ones

Milan Ch. Dutta,1 Kaushik Chanda,1 R. L. Nongkhlaw,2 and Jai N. Vishwakarma1

1Organic Research Lab., Department of Chemistry, St. Anthony's College, Shillong-793 001, India
2Department of Chemistry, North-Eastern Hill University, Shillong-793 022, India

Received 15 June 2009; Accepted 18 July 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A facile microwave assisted one-pot synthetic protocol has been devised for the synthesis of 3,3'-(alkanediyl) bis (1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-ones (2a-c), 3,3'-(1,4-phenylene) bis (1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one (2d),3,3'-(alkanediyl) bis (7,7-dimethyl-1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-ones (2e-g) and 3,3'-(1,4-phenylene) bis(7,7-dimethyl-1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one (2h) by the cyclocondensation of cyclic enaminones 1a, b with diamines and formaldehyde.