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E-Journal of Chemistry
Volume 7, S1, Pages S191-S196
http://dx.doi.org/10.1155/2010/853298

Synthesis and Characterization of Two Danazol Derivatives

Lauro Figueroa-Valverde,1,2 francisco Díaz-Cedillo,2 Maria López-Ramos,1,2 and Elodia Garcia-Cervera1,2

1Facultad de Ciencias Químico-Biológicas, Lab. de Investigación, Universidad Autónoma de Campeche Av. Agustín Melgar s/n, Col Buenavista C.P.24039 Campeche, México
2Escuela de Ciencias Biológicas del IPN. Plan de San Luís y Díaz Mirón s/n Col Santo Tomas, D.F. C.P. 11340, México

Received 16 March 2010; Revised 25 May 2010; Accepted 20 June 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and chemical requirements of danazol derivatives, several parameters such as logP, π, Rm and Vm were evaluated. The results showed an increase in the values of logP for the compound 6 in comparison with 3. The compound 3 showed an increase in the values of π, R Vm and V Vm with respect to 6. These data indicate a high degree of lipophilicity and a low steric impediment for compound 6 in comparison with 3.