Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 904823 | 4 pages | https://doi.org/10.1155/2010/904823

Synthesis and Structure Elucidation of 4-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl-methylene)-2-phenyl-1H-imidazol-5(4H)-one

Received14 Nov 2009
Accepted07 Jan 2010

Abstract

4-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl-methylen)-2-phenyl-1(3H)-imidazol-5-one (5) was synthesized in four steps in high yield. Benzimidinium chloride (1) reacted with dimethyl acetylenedicarboxylate to afford 2-phenyl-4-methoxycarbonylmethylen-1(3H)-imidazol-5-one (2) which was converted to 2-phenyl-4-hydrazinecarbonylmethylen-1(3H)-imidazol-5-one (3) using hydrazine hydrate in methanol. Furthermore, the reaction of (3) with carbon disulfide afforded compound (4) which can be used without further purification to achieve compound (5) using hydrazine hydrate.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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