Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 935279 | https://doi.org/10.1155/2010/935279

R. Kalaichelvi, B. Thangabalan, D. Srinivasa Rao, "Validated RP-HPLC Method for Analysis of Aripiprazole in a Formulation", Journal of Chemistry, vol. 7, Article ID 935279, 6 pages, 2010. https://doi.org/10.1155/2010/935279

Validated RP-HPLC Method for Analysis of Aripiprazole in a Formulation

Received31 Oct 2009
Accepted20 Dec 2009

Abstract

A rapid, simple and validated reversed-phase high-performance liquid chromatographic method has been developed for analysis of aripiprazole in tablet dosage form. Aripiprazole was separated on an ODS analytical column with a 40:60 (v/v) mixture of acetonitrile and triethanolamine buffer (5 mM, pH 3.5 ± 0.05 adjusted by addition of 85% phosphoric acid) as mobile phase at a flow rate of 1.5 mL min-1. The effluent was monitored by UV detection at 254 nm. Calibration plots were linear in the range of 20 to 60 µg mL-1 and the LOD and LOQ were 0.411 and 1.248 µg mL-1, respectively. The high recovery and low relative standard deviation confirm the suitability of the method for routine quality control determination of aripiprazole in tablets.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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