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E-Journal of Chemistry
Volume 7 (2010), Issue 3, Pages 1040-1044

Synthesis and Antifungal Activity of 2-Ketophenyl-3-substituted aryl-1-thiazolidin-4-ones

Vishnu Vats,1 R. K. Upadhyay,1 and Prathibha Sharma2

1Department of Chemistry, N.R.E.C.College, Chaudhary Charan Singh University, Meerut, India
2Department of Plant Pathology, Indian Agricultural Research Institute, New Delhi, India

Received 5 September 2009; Revised 11 November 2009; Accepted 5 January 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new series of 2-ketophenyl-3-substituted aryl-1- thiazolidin-4-ones were synthesized by cyclocondensation of ketoazomethines and thioglycolic acid. Ketoazomethines were synthesized by condensation of phenyl glyoxal (prepared by partial oxidation of acetophenone) and various para-substituted anilines. Their structures were elucidated by elemental analysis, IR and H1 NMR; they were screened for their antifungal activity against hazardous fungi namely Fusarium Oxysporum, Pythium, Sclerotium and Alternaria brassicola.