Journal of Chemistry

Journal of Chemistry / 2010 / Article

Open Access

Volume 7 |Article ID 979401 | https://doi.org/10.1155/2010/979401

K. Narasimha Sarma, M. C. S. Subha, K. Chowdoji Rao, "A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole", Journal of Chemistry, vol. 7, Article ID 979401, 6 pages, 2010. https://doi.org/10.1155/2010/979401

A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

Received31 Aug 2009
Accepted20 Oct 2009

Abstract

The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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