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E-Journal of Chemistry
Volume 7, Issue 3, Pages 745-750
http://dx.doi.org/10.1155/2010/979401

A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

K. Narasimha Sarma, M. C. S. Subha, and K. Chowdoji Rao

Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., India

Received 31 August 2009; Accepted 20 October 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.