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E-Journal of Chemistry
Volume 7, Issue 2, Pages 449-456

Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides

G. P. Suresha, K. C. Prakasha, Wethroe Kapfo, and D. Channe Gowda

Department of Chemistry, Manasagangotri, University of Mysore, Mysore-570006, India

Received 10 September 2009; Accepted 5 November 2009

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Antimicrobial compounds were synthesized by coupling 4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanoic acid with VP, GVP, VGVP and GVGVP peptides. Antimicrobial activities of the synthesized compounds were performed against various bacterial strains by disc diffusion method. The structure activity relationship was evaluated with respect to hydrophobicity, polarity, chain length of peptides and alkyl chain length of quinazolinone. Correlations of analogs with respect to their antimicrobial activity in comparison with conventional drugs and probable mechanism for the activity were discussed.