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E-Journal of Chemistry
Volume 7 (2010), Issue 3, Pages 922-926

Synthesis of Diindolylmethanes (DIMs) Catalyzed by Silicotungstic Acid by Grinding Method

Ji-Tai Li and Shao-Feng Sun

Key Laboratory of Analytical Science and Technology, Hebei Province; Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China

Received 20 November 2009; Accepted 15 January 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The synthesis of diindolylmethanes (DIMs) via the condensation of indole and aromatic aldehydes catalyzed by silicotungstic acid was carried out in 68%~98% yields at room temperature within 1~5 min by grinding. This method provides several advantages such as operational simplicity, higher yield and environment friendly.