Journal of Chemistry

Journal of Chemistry / 2011 / Article

Open Access

Volume 8 |Article ID 258340 |

Mohamed N. Ibrahim, Salaheddin A. I. Sharif, Ahmad N. EL-Tajory, Asma A. Elamari, "Synthesis and Antibacterial Activities of Some Schiff Bases", Journal of Chemistry, vol. 8, Article ID 258340, 5 pages, 2011.

Synthesis and Antibacterial Activities of Some Schiff Bases

Received11 Nov 2010
Accepted05 Jan 2011


Schiff bases p-hydroxybenzylidene-2-carboxyaniline, p-nitrobenz-ylidene-2-carboxyaniline, p-(N, N-dimethyl)aminobenzylidene-2-carboxyaniline, N-(4-hydroxybezylidene)-benzene-1,2-diamine, N--(4-nitrobezylidene)benzene-1,2-diamine, N-(4-(N, N-dimethylaminobezylidene)benzene-1,2-diamine, N-(4-(N,N-dimethylamino)benzylidene)naphthalen-1-amine,N-(4-nitrobenzylidene)naphthalen-1-amine,N--(4-chlorobenzylidene)naphthalen-1-amine,sodium-4-(4-(N,N-dimethyl amino)benzylideneamino)naphthalene-1-sulfonate,sodium -4-(4-nitrobenzylidene-amino)naphthalene-1-sulfonate and sodium-4-(4-chlorobenzylideneamino) naphthalene-1-sulfonate obtained by condensation of aniline and naphthyl-amine derivatives with some aromatic aldehydes were characterized by physical and spectral methods. The biological activity of these products were as antibacterial agents against three species of human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Klebsiella sp. Nearly 50% of these compounds showed reasonable activity against the bacterial species investigated and we found that the antibacterial activity is dependent on the molecular structure of the compounds.

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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