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E-Journal of Chemistry
Volume 8, Issue 1, Pages 386-390
http://dx.doi.org/10.1155/2011/258680

Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives

Deepthi Kini1 and Manjunath Ghate2

1Department of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Bangalore, India
2Department of Pharmaceutical Chemistry, Institute of Pharmacy Nirma University, Ahmedabad-382 481, India

Received 21 May 2009; Revised 21 January 2010; Accepted 15 March 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Number of heterocyclic compounds has been exploited to develop pharmaceutically important molecules, out of which biheterocyclic coumarins are clinically used potential drug candidates showing oral hypoglycemic and antidiabetic activities. A new series of 3-[5'-methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino)thiazolidin-4'-one]coumarin derivatives were designed and synthesized. The title compounds were synthesized from starting material 3- acetyl coumarin. All the synthesized compounds were characterized and screened for hypoglycemic activity. Some of the compounds exhibited promising activity.