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E-Journal of Chemistry
Volume 8, Issue 3, Pages 1044-1051

Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines

Sushil Kumar,1 A. K. Wahi,1 and Ranjit Singh2

1Drug Design & Medicinal Chemistry Research Laboratory, College of Pharmacy, IFTM, Moradabad-244001, India
2School of Pharmaceutical Sciences, Shobhit University, Meerut, India

Received 12 September 2010; Revised 30 November 2010; Accepted 15 December 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5-HTP induced head twitches (5-HT2A antagonism) and catalepsy studies in albino mice. The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserine and risperidone was assessed by calculating from a set of physiochemical properties using software programs. The test compounds (3a-j) demonstrated good similarity values with respect to the standard drugs. Among them, compound 3d has emerged as an important lead compound showing potential atypical antipsychotic like profile.