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E-Journal of Chemistry
Volume 8, S1, Pages S304-S308
http://dx.doi.org/10.1155/2011/426452

Spectrofluorimetric Method for the Estimation of Erlotinib Hydrochloride in Pure and Pharmaceutical Formulations

V. Rajesh,1 V. Jagathi,2 K. Sindhuri,2 and G. Devala Rao2

1M.I.C College of Technology, Vijayawada-521180, India
2K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada-520 010, India

Received 1 October 2010; Accepted 27 November 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple and sensitive spectrofluorimetric method has been developed for the estimation of erlotinib hydrochloride in pure and pharmaceutical dosage forms. Erlotinib hydrochloride exhibits maximum fluorescence intensity in methanol and the Beer's law was obeyed in the range of 1-5 µg/mL at an excitation wavelength (λex) of 295 nm and an emission wavelength (λem) of 339 nm. Stability studies with respect to time and temperature were also carried out. The results obtained were in good agreement with the labelled amounts of the marketed formulations. This method has been statistically evaluated and found to be accurate and precise.