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E-Journal of Chemistry
Volume 8 (2011), Issue 3, Pages 1401-1407
http://dx.doi.org/10.1155/2011/545403

Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics

P. Rashmi,1 Gopal Krishna Rao,3 Kshama Devi,2 B. G. Shivananda,2 G. R. Swetha,3 and G. A. Suneetha2

1Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, India
2Department of Pharmacology , Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, India
3Nargund College of Pharmacy, II Main Dattatreyanagar, Bangalore-560085, India

Received 26 September 2010; Accepted 27 November 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity. A series of new aryl ether derivatives [4(a-h), 5] were prepared by Ullmann’s ether condensation. The structures of new compounds are supported by their IR, 1H NMR and Mass spectra. The new derivatives were evaluated for their antiinflammatory and analgesic activity. Among the tested, compound 3 has shown better antiinflammatory and analgesic activity.