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E-Journal of Chemistry
Volume 8 (2011), Issue 2, Pages 541-546

Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety

S. Sridhar,1 S. C. Dinda,2 and Y. Rajendra Prasad3

1Chebrolu Hanumaiah Institute of Pharmaceutical Sciences Guntur, A.P., India
2School of Pharmaceutical Education and Research Berhampur University, Berhampur, Orissa, India
3University College of Pharmaceutical Sciences Andhra University, Vishakapatanam, A.P., India

Received 21 June 2010; Accepted 2 September 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of new chalcones (3a-g) were prepared by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of their IR, 1H NMR spectral data and elemental analyses. When these chalcones were evaluated for antimicrobial and anti-inflammatory activities, some of them were found to possess significant activity, when compared to standard drugs.