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E-Journal of Chemistry
Volume 8, Issue 3, Pages 1309-1313

Method Development and Validation of Metformin Hydrochloride in Tablet Dosage Form

Kaushelendra Mishra,1 Himesh Soni,2 Govind Nayak,2 Sita Sharan Patel,2 and A. K. Singhai2

1Lakshmi Narain College of Pharmacy, Raisen Road Bhopal (M.P.)-462021, India
2Pharmaceutical Analysis Research Lab., L.N.C.P. Bhopal (M.P.), India

Received 12 October 2010; Accepted 17 December 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple, reproducible and efficient method for the determination of metformin hydrochloride (MET) was developed and validated. The analysis complied with Beer's law in the concentration range of 8-13 μg/mL at 233 nm for MET. In our study the validation of analytical method for determination of MET by UV in tablets formulation was performed in accordance the parameters including-system suitability, specificity, limit of quantification, limit of detection, linearity of response, accuracy, precision (reproducibility & repeatability), robustness (change of wave length±2 nm).