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E-Journal of Chemistry
Volume 8, Issue 1, Pages 240-244
http://dx.doi.org/10.1155/2011/820718

Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents

Anoop K. Pathak, Viney Chawla, and Shailendra K. Saraf

Faculty of Pharmacy, Northern India Engineering College Sector-2, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow-227105, India

Received 29 April 2010; Accepted 17 July 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new series of 1,3-pyrimidine derivatives (3a-f) have been synthesized by reacting 2,4,6-Trichloropyrimidine with nucleophilic reagents 2-amino-6-fluorobenzothiazole (1) in the presence of acetone. The (4,6- dichloro-pyrimidin-2-yl)-amine (2) so produced was then reacted to two moles of phenylthiourea derivatives to yield title compounds (3a-f). The structural assessment of the compounds (3a-f) was made on the basis of spectral data. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., B. subtilis, E. coli, P. aeruginosa and S. aureus using agar diffusion technique. Compounds 3c and 3f exhibited highest antibacterial activity.