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E-Journal of Chemistry
Volume 8 (2011), Issue 3, Pages 1226-1231

Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives

Eskandar Alipour,1 Negar Mohammad Hosseini,1 Fatemeh Panah,2 Sussan K. Ardestani,2 Maliheh Safavi,3 Abbas Shafiee,3 and Alireza Foroumadi4

1Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran
2Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran
3Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
4Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Received 21 September 2010; Accepted 22 November 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N-pipearzinyl quinolones containing N-2-(furyl-2-yl)-2-(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7-(4-(2-(3-chlorobenzyloxyimino)-2-(furan-2-yl) ethyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines.