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E-Journal of Chemistry
Volume 8, Issue 3, Pages 1108-1113

Synthesis of N-Methyl-6-heterocyclic-1-oxoisoindoline Derivatives by Microwave Assisted Buchwald-Hartwig Amination

C. Kishor Kumar, H. Vijay Kumar, and Nagaraja Naik

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India

Received 21 November 2010; Accepted 22 January 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An rapid and efficient microwave assisted Pd(II) catalyzed protocol for the preparation of N-methyl-6-heterocyclic-1-oxoisoindoline derivatives by Buchwald-Hartwig amination with an overall yield 68-85% has been described.