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E-Journal of Chemistry
Volume 8, Issue 1, Pages 245-251
http://dx.doi.org/10.1155/2011/873470

Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity

Kartick Chandra Samanta,1 Mohd. Asif,2 Pooja,1 Vikas Garg,3 Priyanka Sharma,1 and Ravinder Singh4

1School of Pharmacy, Suresh Gyan Vihar University, Jaipur-302025, India
2Department of Pharmacy, GRD (PG) Institute of Management & Technology214, Rajpur Road, Dehradun, Uttarakhand, India
3Manipal College of Pharmaceutical Sciences, Manipal-576104, India
4Nandha College of Pharmacy and Research Institute, Erode, Tamilnadu, India

Received 31 January 2010; Accepted 1 March 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.