Synthesis, Characterization and Antibacterial Activity of Novel Schiff Bases Derived from 4-Phenyl-2-aminothiazole and their Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) Metal complexes

Abstract

Novel Schiff bases and their metal complexes were derived from some hetero cyclic β-diketones with 4-phenyl-2-aminothiazole. All the synthesized compounds were confirmed their structure by Elemental analysis, FT-IR, ¹H NMR, ¹³C NMR, Mass spectra, TGA analysis and UV spectra. All the compounds were tested for their antibacterial activity. Spectroscopic measurements suggest that all Schiff base metal complexes are of type ML₂.(H₂O)₂ (M=Mn, Fe, Co, Ni and Cu) and all the metal complexes shows moderate antibacterial activity in the agar cup assay method.