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E-Journal of Chemistry
Volume 8, Issue 2, Pages 594-597

Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole

Shiv K. Gupta,1 P. K. Sharma,2 M. Bansal,2 and B. Kumar1

1Department of Pharmaceutical Science, Shree Ganpati Institute of Technology, NH-24, opp. Jindal Pipes Ltd, Ghaziabad, India
2Meerut Institute of Engineering and Technology, Partapur Road, Bagpat Croosing, Meerut, India

Received 10 July 2010; Accepted 3 September 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.